Article révisé par les pairs
Résumé : Actinomycin binding, which is considered as an expression of genetic activity, has been evaluated in acute and chronic lymphatic leukaemia cells and compared with values for both normal cells and pathologically (infectious mononucleosis) or PHA-stimulated lymphocytes. A significant increase in binding accompanies lymphocyte activation. In acute leukaemia, the binding values were well above those observed in normal cells, and differences were noted between the proliferating and non-proliferating blasts. In chronic lymphatic leukaemia, on the other hand, actinomycin binding is considerably decreased. This is taken as a sign of marked changes in genetic regulation. © 1972 S. Karger AG, Basel.