The effects of aphidicolin, an inhibitor of DNA replication, on sea urchin development.

Brachet, Jean; De Petrocellis, B

doi:doi/10.1016/0014-4827(81)90310-4

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The effects of aphidicolin, an inhibitor of DNA replication, on sea urchin development.

par Brachet, Jean

;De Petrocellis, B
Référence Experimental cell research, 135, 1, page (179-189)
Publication Publié, 1981-09

Article révisé par les pairs

Résumé :

Aphidicolin, an inhibitor of DNA polymerase α, arrests DNA synthesis without affecting RNA and protein synthesis at all stages of sea urchin development. Cleavage is quickly stopped and hatching is prevented by the presence of the drug at 2 μg/ml. Treatment with aphidicolin of young blastulae prevents gastrulation, but inhibition of archenteron invagination and skeleton formation is incomplete when the drug is added to late blastulae or early gastrulae. The role of cell division in gastrulation is discussed. © 1981.

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