par Hocq, Aline;Luhmer, Michel 
;Saussez, Sven ;Louryan, Stéphane ;Gillis, Pierre ;Gossuin, Yves
Référence Contrast Media & Molecular Imaging
Publication Publié, 2014
;Saussez, Sven ;Louryan, Stéphane ;Gillis, Pierre ;Gossuin, YvesRéférence Contrast Media & Molecular Imaging
Publication Publié, 2014
Article révisé par les pairs
| Résumé : | Iron accumulation is observed in liver and spleen during hemochromatosis and important neurodegenerative diseases involve iron overload in brain. Storage of iron is ensured by ferritin, which contains a magnetic core. It causes a darkening on T2-weighted MR images. This work aims at improving the understanding of the NMR relaxation of iron-loaded human tissues, which is necessary to develop protocols of iron content measurements by MRI. Relaxation times measurements on brain, liver and spleen samples were realized at different magnetic fields. Iron content was determined by atomic emission spectroscopy. For all samples, the longitudinal relaxation rate (1/T1) of tissue protons decreases with the magnetic field up to 1 T, independently of iron content, while their transverse relaxation rate (1/T2) strongly increases with the field, either linearly or quadratically, or a combination thereof. The extent of the inter-echo time dependence of 1/T2 also varies according to the sample. A combination of theoretical models is necessary to describe the relaxation of iron-containing tissues. This can be due to the presence, inside tissues, of ferritin clusters of different sizes and densities. When considering all samples, a correlation (r2 |
