par Lejeune, Ferdinand 
;Lienard, Danielle ;Ewalenko, Patricia
Référence World journal of surgery, 12, 3, page (345-348)
Publication Publié, 1988
;Lienard, Danielle ;Ewalenko, Patricia Référence World journal of surgery, 12, 3, page (345-348)
Publication Publié, 1988
Article révisé par les pairs
| Résumé : | In order to prevent recurrence, isolation perfusion was applied in 15 patients after resection of sarcomas of the limbs. There were 6 liposarcomas, 4 synoviosarcomas, 2 malignant fibrohistiocytomas, 1 malignant mesenchynoma, 1 Kaposi, and 1 osteosarcoma (the only bone sarcoma). Eight sarcomas were recurrent after narrow surgery and/or radiotherapy. The treatment schedule was conducted in 2 steps: (a) removal of the tumor with safety margins at least outside the tumor capsule, followed 3-8 weeks later by (b) isolation perfusion with melphalan with or without actinomycin D under moderate hyperthermia at 39-41°C for 1 hour. Median follow-up time has been 30 months. Four of the 8 recurrent sarcomas recurred again and developed distal metastases. In contrast, none of the previously untreated patients recurred and 1 disseminated in the form of multicentric liposarcoma. Eleven are still alive with survival ranging from 8 to 103 months. It is concluded that isolation perfusion with melphalan with or without actinomycin D may be considered as an adjunct to surgery. |
