par Welraeds, Daniel
Référence Current therapeutic research, 55, 12, page (1509-1517)
Publication Publié, 1994
Article révisé par les pairs
Résumé : A randomized, open-label, comparative study was undertaken to assess the analgesic efficacy of piroxicam and piritramide in 57 inpatients who underwent orthopedic/traumatologic surgery. They received either piroxicam 40 mg or piritramide 20 mg in a single intramuscular (IM) dose after surgery and a second IM dose the next morning, Supplemental analgesic medication (usually paracetamol) was given at the patient's request during the postoperative period. Up to 3 days after surgery, both drugs were highly effective, relieved the pain significantly (P < 0.001), and were rated statistically equivalent on three pain scales. No difference was detected between the two groups regarding the need for supplemental analgesic medication, except on day 2, when 36% of the piritramide-treated patients requested supplemental analgesics versus 8% of piroxicam-treated patients. A low incidence of mainly mild side effects was reported with both medications. Results confirm those of short-term postoperative/posttraumatologic and other pain studies in which piroxicam provided good analgesia and was well tolerated. The two agents studied provided comparable and significant pain relief after orthopedic/ traumatologic surgery.

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