par Biot, Christophe 
;Dessolin, Jean;Ricard, Isabelle;Dive, Daniel
Référence Journal of organometallic chemistry, 689, 25 SPEC. ISS., page (4678-4682)
Publication Publié, 2004-12
;Dessolin, Jean;Ricard, Isabelle;Dive, DanielRéférence Journal of organometallic chemistry, 689, 25 SPEC. ISS., page (4678-4682)
Publication Publié, 2004-12
Article révisé par les pairs
| Résumé : | Starting from triazacyclononane, easily accessible ferrocenic quinoline derivatives were synthesized. Their antiplasmodial properties were investigated against chloroquine sensitive (HB3) and chloroquine-resistant (Dd2) Plasmodium falciparum. One of them, 7-chloro-4-[4-(7-chloro-4-quinolyl)-7-ferrocenylmethyl- 1,4,7- triazacyclononan-1-yl]quinoline (4) showed potent antimalarial activity in vitro against the chloroquine-resistant strain Dd2 and therefore revealed to be the most promising lead from the present work for new organometallic antimalarial agents. © 2004 Elsevier B.V. All rights reserved. |
