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Signal separation and determination of the enantiomeric purity of primary amines with (-)-myrtenal - a 13C NMR study

par Dufrasne, François ;Gelbcke, Michel ;Galanski, Markus
Référence Spectrochimica acta. Part A: Molecular and biomolecular spectroscopy, 65, 3-4, page (869-873)
Publication Publié, 2006-11

Article révisé par les pairs

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Résumé :

The applicability of (-)-myrtenal as a chiral derivatizing agent in combination with 13C NMR spectroscopy was investigated. 13C NMR was found to be a valuable tool for the identification and enantiomer differentiation of primary amines including β-amino alcohols and vicinal diamines. The enantiomeric excess could be determined via automated deconvolution and integration, and was found to be in good accordance with the expected values even in the cases, when enantiomer differentiation was not possible in 1H NMR spectra. © 2006 Elsevier B.V. All rights reserved.