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Binding capacities of various analogues of S-adenosyl-L-homocysteine to protein methyltransferase II from human erythrocytes

par Gillet, Laurent;Looze, Yvan ;Deconinck, Marc Melchior ;Leonis, José
Référence Experientia, 35, 8, page (1007-1009)
Publication Publié, 1979

Article révisé par les pairs

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Résumé :

A series of analogues of S-adenosyl-L-homocysteine, modified mainly in the amino acid portion of the molecule, have been synthesized. All were found to be competitive inhibitors of protein methyltransferase II from human erythrocytes. S-adenosyl-L-homocysteine remains however by far the most effective inhibitor of the methylase. © 1979 Birkhäuser Verlag.