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Phosphate metabolism and foetal growth in the rat. I. Net transfer of 31P and 32P inorganic phosphate from the maternal plasma to the normal placenta

par Van Bogaert, Eric;Gueuning, Christiane ;Graff, Guy
Référence Archives internationales de physiologie et de biochimie, 89, 4, page (303-312)
Publication Publié, 1981

Article révisé par les pairs

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Résumé :

Net transfer of 31P and 32P inorganic phosphate from the maternal plasma to the rat chorio-allantoic placenta has been studied after intraperitoneal injection of [32P]ortho-phosphate in primigravid females at the 12th day or later stages of gestation. The concentration and label uptake per unit weight of placenta of the inorganic phosphate (P1), organic-bound acid-soluble phosphate (POAS) and organic-bound acid-insoluble phosphate (POAIS) fractions are negatively correlated with increasing placental weight, whereas their specific activities are independent of placental weight. The amount and label uptake per whole placenta of the P1, POAS and POAIS fractions are positively correlated with increasing placental weight. The placental concentrations of inorganic phosphate and calcium are positively related without, however, any marked accumulation of calcium. The growing placenta is thus shown to reduce progressively, on a unit weight basis, both the inorganic phosphate uptake from the maternal plasma and its further incorporation into organic-bound fractions. There is no evidence of a control by the foetal weight, acting per se, on these placental activities.