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The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: The D:A:D study

par Kamara, David;Worm, Signe Westring;Reiss, Peter;Rickenbach, Martin;Phillips, Andrew N.;Kirk, Ole;d'Arminio Monforte, Antonella;Bruyand, Mathias;Law, Matthew;De Wit, Stéphane ;Smith, Colette;Pradier, Christian;Lundgren, Jens D;Sabin, Caroline
Référence The Journal of infectious diseases, 204, 4, page (521-525)
Publication Publié, 2011-08

Article révisé par les pairs

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Résumé :

We assessed whether fasting modifies the prognostic value of these measurements for the risk of myocardial infarction (MI). Analyses used mixed effect models and Poisson regression. After confounders were controlled for, fasting triglyceride levels were, on average, 0.122 mmol/L lower than nonfasting levels. Each 2-fold increase in the latest triglyceride level was associated with a 38% increase in MI risk (relative rate, 1.38; 95% confidence interval, 1.26-1.51); fasting status did not modify this association. Our results suggest that it may not be necessary to restrict analyses to fasting measurements when considering MI risk. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.