par Pelekanou, Vasiliki 
;Leclercq, Guy
Référence The International journal of developmental biology, 55, 7-9, page (869-878)
Publication Publié, 2011
;Leclercq, Guy Référence The International journal of developmental biology, 55, 7-9, page (869-878)
Publication Publié, 2011
Article révisé par les pairs
| Résumé : | The present workreviews recent findings related to the action of steroidal (physiolo-wworkk reviewws fifindings ((physiological) estrogens on normal mammary gland development and carcinogenesis, as wwell as effects of related environmental mediators phyto- and xeno-estrogens), the role of wwhich remains controversial. Orchestration by estrogen receptors i.e. ERα and ERβ) and coregulators of growwth, apoptosis and differentiation of epithelial cells, directed our analysis. The bidirectional coordination betwween epithelium and stroma in parallel wwith maintenance of stemness are also investigated. The relevance of nuclear and extranuclear localization of ERs and other eventual estrogen binding sites, mediating differential actions in regard to these various topics, is critically addressed to delineate the importance of direct and indirect activation procedures and delicate feedbackk loops ((ligand-induced or/and cross-talkk activation, respectively). The inclusion of the outlined regulatory concepts in drug design programs for the prevention and treatment of breast cancer may have potent effects. © 2011 UBC Press. |
