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Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients

par Antypa, Niki;Calati, Raffaella;Souery, Daniel ;Pellegrini, Silvia;Sentissi, Othman;Amital, Daniela;Moser, Ulrike;Montgomery, Stuart;Kasper, Siegfried;Zohar, Joseph;De Ronchi, Diana;Mendlewicz, Julien ;Serretti, Alessandro
Référence Journal of affective disorders, 150, 2, page (649-652)
Publication Publié, 2013-09

Article révisé par les pairs

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Résumé :

Background: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. Methods: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). Results: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. Limitations: These findings did not survive correction for multiple testing and should be interpreted with caution. Conclusion: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. © 2013 Elsevier B.V.