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A multicenter phase 1 study of EMD 525797 (DI17E6), a novel humanized monoclonal antibody targeting αv integrins, in progressive castration-resistant prostate cancer with bone metastases after chemotherapy

par Wirth, Manfred M.P.;Heidenreich, Axel;Gschwend, Jürgen J.E.;Gil, Thierry ;Zastrow, Stefan;Laniado, Michael;Gerloff, Joachim;Zühlsdorf, Michael;Mordenti, Giacomo;Uhl, Wolfgang;Lannert, Heinrich
Référence European urology, 65, 5, page (897-904)
Publication Publié, 2014

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Titre:	A multicenter phase 1 study of EMD 525797 (DI17E6), a novel humanized monoclonal antibody targeting αv integrins, in progressive castration-resistant prostate cancer with bone metastases after chemotherapy
Auteur:	Wirth, Manfred M.P.; Heidenreich, Axel; Gschwend, Jürgen J.E.; Gil, Thierry; Zastrow, Stefan; Laniado, Michael; Gerloff, Joachim; Zühlsdorf, Michael; Mordenti, Giacomo; Uhl, Wolfgang; Lannert, Heinrich
Informations sur la publication:	European urology, 65, 5, page (897-904)
Statut de publication:	Publié, 2014
Sujet CREF:	Néphrologie - urologie
Mots-clés:	Castrate-resistant prostate cancer (CRPC)
	EMD 525797
	αv-Integrin overexpression
MeSH keywords:	Adult
	Aged
	Aged, 80 and over
	Antibodies, Monoclonal, Humanized -- administration & dosage -- adverse effects -- pharmacokinetics
	Antineoplastic Agents -- administration & dosage -- adverse effects -- pharmacokinetics
	Bone Neoplasms -- blood -- drug therapy -- secondary
	Disease-Free Survival
	Drug Eruptions -- etiology
	Humans
	Integrin alphaV -- immunology
	Male
	Middle Aged
	Pain Measurement
	Prostate-Specific Antigen -- blood
	Prostatic Neoplasms, Castration-Resistant -- blood -- drug therapy -- pathology
	Sepsis -- chemically induced
	gamma-Glutamyltransferase -- blood
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0302-2838
	info:doi/10.1016/j.eururo.2013.05.051
	info:pii/S0302283813005654
	info:scp/84896402680
	info:pmid/23791392