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Approches expérimentale et de modélisation de la signalisation calcique dans les cellules

par Combettes, Laurent;Dupont, Geneviève
Référence MS. Médecine sciences, 27, 2, page (170-176)
Publication Publié, 2011-02

Article révisé par les pairs

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Résumé :

In many cell types, specific and robust signalling relies on a high level of spatiotemporal organization of Ca2+ dynamics. In response to external stimulation, Ca2+ signals ranging from a small increase of a few tens of nanomolar concentrations ot the mouth of an inositol 1, 4, 5-trisphosphate receptor to the periodic propagation of waves invading an organ or a tissue, can be observed. Here, we review our combined experimental and computational approach of Ca2+ dynamics, which has been mainly carried out on liver hepotocytes. We focus in particular on the understanding of the relationship between elementary Ca2+ increases, Ca2+ oscillations and intra- or intercellular Ca2+ waves. The physiological impact of such signalling on liver function is also discussed.