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Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: Implications for antiviral therapy

par Andrei, Graciela;Georgala, Aspasia ;Topalis, Dimitri;Fiten, Pierre;Aoun, Michel ;Opdenakker, Ghislain;Snoeck, Robert
Référence The Journal of infectious diseases, 207, 8, page (1295-1305)
Publication Publié, 2013-04

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Titre:	Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: Implications for antiviral therapy
Auteur:	Andrei, Graciela; Georgala, Aspasia; Topalis, Dimitri; Fiten, Pierre; Aoun, Michel; Opdenakker, Ghislain; Snoeck, Robert
Informations sur la publication:	The Journal of infectious diseases, 207, 8, page (1295-1305)
Statut de publication:	Publié, 2013-04
Sujet CREF:	Allergie et immunopathologie
	Pathologie maladies infectieuses
Mots-clés:	DNA polymerase
	drug-resistance dynamics in HSV
	evolution of HSV populations
	hematopoietic stem cell transplantation (HSCT)
	heterogenicity of HSV populations
	multiple HSV infections
	thymidine kinase
MeSH keywords:	Acyclovir -- pharmacology
	Adult
	DNA, Viral -- analysis -- genetics
	Drug Resistance, Multiple, Viral
	Evolution, Molecular
	Female
	Ganciclovir -- pharmacology
	Genes, pol
	Genetic Heterogeneity
	Genotype
	Hematopoietic Stem Cell Transplantation
	Herpesvirus 1, Human -- enzymology -- genetics -- isolation & purification
	Humans
	Leukemia, Myeloid, Acute -- pathology
	Mutation
	Phenotype
	Stomatitis, Herpetic -- drug therapy -- pathology -- virology
	Thymidine Kinase -- genetics
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0022-1899
	info:doi/10.1093/infdis/jit019
	info:pii/jit019
	info:scp/84875605435
	info:pmid/23315323