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Inhibitory effect of cholecystokinin octapeptide on neurons in the nucleus tractus solitarius

par Morin, M.P.;De Marchi, P.;Champagnat, Jean Claude;Vanderhaeghen, Jean-Jacques ;Rossier, Jean;Denavit-Saubie, Monique
Référence Brain research, 265, 2, page (333-338)
Publication Publié, 1983-04

Article révisé par les pairs

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Résumé :

We investigated the effect of the cholecystokinin octapeptide (CCK8) applied locally to neurons of the nucleus tractus solitarius (NTS). Results demonstrate an inhibitory effect of CCK8 on spike discharges including those related to respiration. It is suggested that CCK8 acts at this level through specific receptor mechanisms since CCK8-induced inhibitions were not reproduced by application of related peptides and were resistant to antagonists of different inhibitory transmitters. © 1983.