par D'Hollander, Alain 
;Delcroix, Claude ;Duvaldestin, Philippe;Henzel, Danielle;Coussaert, Edouard ;Desmonts, Jean Maríe
Référence European Journal of Clinical Pharmacology, 24, 3, page (407-413)
Publication Publié, 1983-05
;Delcroix, Claude ;Duvaldestin, Philippe;Henzel, Danielle;Coussaert, Edouard ;Desmonts, Jean MaríeRéférence European Journal of Clinical Pharmacology, 24, 3, page (407-413)
Publication Publié, 1983-05
Article révisé par les pairs
| Résumé : | The neuromuscular blocking characteristics and plasma concentration decay of fazadinium bromide, a short acting, non-depolarizing muscular relaxant, were simultaneously observed under standardised conditions in 6 healthy, anaesthetized, adult patients. The results were analyzed by a new pharmacodynamic model, which takes into account certain relationships describing the binding of non-depolarizing neuromuscular blocking agents and the postsynaptic receptor occupation ratio. According to the simulations performed, the pharmacodynamic parameters determined: KB-apparent value of equilibrium constant of fazadinium - receptors exchange (mean ± SEM) 0.404+0.045 μmol/l, and the value of postsynaptic occupation ratio for 50% paralysis of 0.89±0.004 were in agreement with values reported in the literature for mammalian neuromuscular junctions in vitro. The apparent validity of the pharmacodynamic model and its value in simulating dose/effect relationships of non-depolarizing neuromuscular blocking agents are discussed and illustrated. © 1983 Springer-Verlag. |
