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Antiretroviral drug-related liver mortality among HIV-positive persons in the absence of hepatitis B or C virus coinfection: The data collection on adverse events of anti-HIV drugs study

par Kovari, Helen;Sabin, Caroline;Ledergerber, Bruno;Ryom, Lene;Worm, Signe Westring;Smith, Colette;Phillips, AN;Reiss, Peter;Fontas, Eric;Petoumenos, Kathy;De Wit, Stéphane ;Morlat, Philippe;Lundgren, Jens D;Weber, Rainer
Référence Clinical infectious diseases, 56, 6, page (870-879)
Publication Publié, 2013-03

Article révisé par les pairs

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Résumé :

Background. Liver diseases are the leading causes of death in human immunodeficiency virus (HIV)-positive persons since the widespread use of combination antiretroviral treatment (cART). Most of these deaths are due to hepatitis C (HCV) or B (HBV) virus coinfections. Little is known about other causes. Prolonged exposure to some antiretroviral drugs might increase hepatic mortality. Methods. All patients in the Data Collection on Adverse Events of Anti-HIV Drugs study without HCV or HBV coinfection were prospectively followed from date of entry until death or last follow-up. In patients with liver-related death, clinical charts were reviewed using a structured questionnaire.Results. We followed 22 910 participants without hepatitis virus coinfection for 114 478 person-years. There were 12 liver-related deaths (incidence, 0.10/1000 person-years); 7 due to severe alcohol use and 5 due to established ART-related toxicity. The rate of ART-related deaths in treatment-experienced persons was 0.04/1000 person-years (95% confidence interval,. 01,. 10). Conclusions. We found a low incidence of liver-related deaths in HIV-infected persons without HCV or HBV coinfection. Liver-related mortality because of ART-related toxicity was rare. © 2012 The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.