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Patterns of plasma levels of prednisolone after oral administration in man

par Leclercq, Raoul ;Copinschi, Georges
Référence Journal of Pharmacokinetics and Biopharmaceutics, 2, 2, page (175-187)
Publication Publié, 1974

Article révisé par les pairs

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Résumé :

A competitive protein binding method was found suitable for the estimation of plasma prednisolone levels in men in whom endogenous steroids were suppressed by dexamethasone premedication. This method is rapid and precise and allows measurements of prednisolone in small blood samples after usual therapeutic doses of the drug. Using this technique, two preparations of the medication were compared, a conventional form and an enteric coated formulation; except for the delay due to the coating, they were completely comparable, since maximum levels reached, areas under the plasma concentration time curves, and apparent disappearance half lifes were almost identical.