Article révisé par les pairs
Résumé : The influence of norepinephrine (NE), human growth hormone (HGH) and fasting on FFA mobilization and carbohydrate metabolism has been studied in 47 obese females and 72 nonobese control subjects (35 females and 37 males). - Weight-related doses of NE infused for 2 h (0.1 γ/kg/min) induced a much greater rise in plasma FFA and blood glucose concentrations in obese than in normal subjects. With a fixed dose (10 γ/min for 2 h), FFA response was still significantly higher in the overweight than in the lean subjects, while glucose réponses were similar in both groups. Among the control subjects, males and females behaved similarily. - The plasma FFA rise observed in the 4 h following the i. v. injection of HGH (10 mg) was not statistically different in obese females, normal males and normal females. - These results suggest that human obese adipose tissue has no impaired sensitivity toward the lipolytic action of NE and HGH. - During fasting, obese, when compared with normal subjects, showed a smaller increase in plasma FFA level together with a smaller decrease in glucose flux. The possible relationship between these 2 anomalies is discussed, considering that glucose deficiency has a major role in regulating FFA mobilization during fasting. © 1968 Springer-Verlag.