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5-Substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials

par Biot, Christophe ;Bauer, Holger G.;Schirmer, Rolf Heiner;Davioud-Charvet, Elisabeth
Référence Journal of medicinal chemistry, 47, 24, page (5972-5983)
Publication Publié, 2004-11

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Titre:	5-Substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials
Auteur:	Biot, Christophe; Bauer, Holger G.; Schirmer, Rolf Heiner; Davioud-Charvet, Elisabeth
Informations sur la publication:	Journal of medicinal chemistry, 47, 24, page (5972-5983)
Statut de publication:	Publié, 2004-11
Sujet CREF:	Biologie moléculaire
	Pharmacologie
MeSH keywords:	Animals
	Antimalarials -- chemical synthesis -- chemistry -- pharmacology
	Biological Availability
	Caproates -- chemical synthesis -- chemistry -- pharmacology
	Cell Line
	Drug Resistance
	Glutathione Reductase -- antagonists & inhibitors -- chemistry
	Humans
	Ligands
	Models, Molecular
	Molecular Structure
	Naphthoquinones -- chemical synthesis -- chemistry -- pharmacology
	Plasmodium falciparum -- drug effects
	Prodrugs -- chemical synthesis -- chemistry -- pharmacology
	Quantitative Structure-Activity Relationship
	Tetrazoles -- chemical synthesis -- chemistry -- pharmacology
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm0497545
	info:scp/8644263983
	info:pmid/15537352
	VX-003074