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Relation between the toxicity of silica and its affinity for tetraalkylammonium groups. Comparison between Si02 and Ti02

par Depasse, Jacques ;Warlus, Jean
Référence Journal of colloid and interface science, 56, 3, page (618-621)
Publication Publié, 1976-09

Article révisé par les pairs

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Résumé :

Coagulation experiments show that tetramethylammonium ions have a strong affinity for SiO2 particles and a very weak affinity for TiO2. Since tetraalkylammonium groups are present in the extracellular region of the erythrocyte membrane, it could explain why erythrocytes are lysed by SiO2, but not by TiO2. As the membrano-toxicity of silica is related to its fibrogenic activity, the strong affinity of SiO2 particles for tetraalkylammonium groups could be implicated in silicosis. The experiments also give some information about the interactions between silica and the positively charged groups of proteins. © 1976.