par Vokaer, Roger 
Référence Journal de gynécologie obstétrique et biologie de la reproduction, 3, 3, page (379-400)
Publication Publié, 1974
Référence Journal de gynécologie obstétrique et biologie de la reproduction, 3, 3, page (379-400)
Publication Publié, 1974
Article révisé par les pairs
| Résumé : | It is very important to know the final hormonal 'climate' under which a woman who is taking hormonal contraception will live for long periods of time. Taking into consideration all observations that were made in this respect there is hardly any possibility that a combined estrogen progestogen antiestrogen pill could prove to be carcinogenetic. There is no reason to think at the present time that oral contraception could have any carcinogenetic effect. It is necessary to repeat, however, that as far as oral contraception is concerned the same difficulties are found in studying every new medicine when attempting to find out how carcinogenetic it is likely to be in human use. At the present time due to clinical prospective and retrospective studies that can be examined, all contraception has no carcinogenic action in the uterus concerning either the pavement epithelium of the exocervix or the endocervical mucosa or the endometrium. As far as the carcinogenetic effects of oral contraceptives on the breast are concerned it is feared both on theoretical and experimental grounds that the hormone imbalance which their use provokes could cause proliferation of cancerous cells that are already present. There is, at present no formal proof to support such a hypothesis. On the other hand all authors agree in stating that combination estrogen progestogen pills when used for oral contraception do not cause breast cancer. Considering the chance of an obnoxious action from the use of these combined hormone preparations, it is recommended that, before giving a prescription for them to anybody, that a complete medical examination should be carried out including a cancer screening of the uterus. A clinical examination and a thermographic and radiographic examination of the breasts should also be carried out. Furthermore, during treatment with the pills these examinations should be repeated at least once a year in order to be able to diagnose any cancerous lesion at the stage when it is still curable. In conclusion, the most serious studies of the action of the contraceptive pill to date have failed to show that such a pill is able to cause cancer in any of the hormone dependent organs. |
