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Fructose 2,6-bisphosphate in yeast

par Lederer, Béatrice;Vissers, Stephan ;Van Schaftingen, Emile;Hers, Henri-Géry
Référence Biochemical and biophysical research communications, 103, 4, page (1281-1287)
Publication Publié, 1981-12

Article révisé par les pairs

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Résumé :

Fructose 2,6-bisphosphate was identified in Saccharomyces cerevisiae grown on glucose both by its property to be an acid-labile stimulator of 6-phosphofructo 1-kinase and by its ability to be quantitatively converted into fructose 6-phosphate under mild acid conditions. Fructose 2,6-bisphosphate was undetectable in cells grown on non-glucose sources. When glucose was added to the culture, fructose 2,6-bisphosphate was rapidly synthesized, reaching within 1 min concentrations able to cause a profound inhibition of fructose 1,6-bisphosphatase and a great stimulation of 6-phosphofructo 1-kinase. © 1981.