par Brohée, Dany ;Kennes, Bernard ;Neve, Pierre
Référence International journal of immunopharmacology, 7, 5, page (739-746)
Publication Publié, 1985
Article révisé par les pairs
Résumé : In our previous studies it was found the E-rosette dissociation and sheep-erythrocyte capping were active processes involving the cytoskeleton. These cellular functions are now shown to be very sensitive to phenothiazine-drugs whose activities can be differentiated as follows: trifluoperazine > chlorpromazine > sulfoxide derivatives, suggesting a role for calmodulin-mediated events. These findings are in contradiction to prior reports pointing to the inefficacy of chlorpromazine to inhibit slow kinetic capping. However, no co-capping of trifluoperazine fluorescence (as a probe of calmodulin) and sheep erythrocytes could be observed. No requirement in extracellular calcium was evident for E-rosette formation and dissociation.