par Hermans, Philippe
Référence Forum (Genoa, Italy), 4, 5, page (539-545)
Publication Publié, 1994
Article révisé par les pairs
Résumé : Acquired immunodeficiency syndrome (AIDS) related Kaposi's sarcoma (KS) is the most frequent tumour in 20% of human immunodeficiency virus (HIV) patients. Its peculiar distribution among patients with sexually acquired HIV infection and its recent decline over a period of time suggest a putative role of a transmissible causative agent that is not yet defined. Hypothesis and potential pathogenic factors associated with angiogenesis and tumour growth in vitro or in animal models will be discussed. A greater experience of these phenomena leading to endothelial proliferation, angiogenesis, edema and spindle cell proliferation could have a major influence not only on further treatment of AIDS associated KS but also on other pathogenic angiogenic processes such as metastases of other cancers. The current palliative therapeutic approaches of AIDS KS will be reviewed as well as new perspectives in the management of this still enigmatic tumour.