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Ciblage du récepteur aux facteurs de croissance épithé liaux (REGF) par les inhibiteurs de tyrosine kinase et applications dans les cancers colorectaux

par Magne, Nicolas;Toillon, Robert-Alain
Référence Oncologie, 6, 1, page (41-45)
Publication Publié, 2004-02

Article révisé par les pairs

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Résumé :

EGF receptor is moderately overexpressed in colorectal cancer and it is globally associated to poor prognosis outcome. Thus determination of EGFR level represents a major interest in order to orientate a targeted therapy and to redefine a new prognostic biological marker to treat colorectal cancer patients. In vitro studies conduced with tyrosine kinase inhibitors in colorectal cancer cell lines have demonstrated additive effects with conventional treatment and molecular biology could explained these positive interactions. Basis on these preclinical studies, future large clinical trials could create a real hope for all patients presenting a colorectal cancer.