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Microbiological aspects of Helicobacter pylori

par De Koster, Erik
Référence European journal of gastroenterology & hepatology, 5, SUPPL. 2, page (S33-S35)
Publication Publié, 1993

Article révisé par les pairs

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Résumé :

Background: Since the first isolation of Helicobacter pylori a decade ago, knowledge of this bacterium and understanding of gastric physiology and pathophysiology has advanced rapidly. Aim: To review the present state of knowledge of H. pylori. Conclusions: H. pylori is especially adapted to its ecological niche in the gastric mucus and on gastric epithelial cells. Bacterial (enzymes, ammonia, toxin) and host factors are responsible for marked tissue damage. Culture of the bacteria allows resistance testing, which is of critical importance for treatment, and determination of virulence factors, which may become important in selecting patients for primary prevention of peptic ulcer disease and gastric cancer.