par Hiden, M.;Heimann, Paul;Goffin, Yves 
;Cornwell III, Gibbons
Référence Qualitative health research, 6, 4, page (211-214)
Publication Publié, 1996
;Cornwell III, GibbonsRéférence Qualitative health research, 6, 4, page (211-214)
Publication Publié, 1996
Article révisé par les pairs
| Résumé : | This study is based on 2 series of amyloid-containing porcine aortic valves explanted from patients. Amyloid was detected by Congo red positivity under polarised light. A first study of 24 cases investigated the histotopography of the deposits inside the cusps. In 23 valves, the deposits predominated in the paracommissural areas where the degradation results from abnormal mechanical stress. A panel of antisera specific for amyloid AλII, AkI, TTR (transthyretin), AA types and P component in a second series of 22 cases was used. All deposits were potassium-permanganate, resistant and contain the amino acid tryptophan. They did react with anti-P component but not with the specific antisera. Our results show that amyloid of long term implanted valvular bioprostheses arises in the most degraded areas and is distinct from other known types of amyloid fibril proteins. It is likely that this amyloidosis is identical to the localized dystrophic type observed in human sclerocalcific valves. |
