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Hemodynamics of patients with renal failure treated with recombinant human erythropoietin

par Verbeelen, Dirk;Bossuyt, Audrey;Smitz, J.;Herman, Arnold;Dratwa, Max ;Jonckheer, M.
Référence Clinical nephrology, 31, 1, page (6-11)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

Hemodynamics were evaluated in 8 patients with uncomplicated renal failure on regular dialysis before and after partial correction of anemia by treatment with recombinant human erythropoietin (r-huEPO). Under r-huEPO treatment, mean (± SD) hemoglobin increased from 7.51 (0.60) to 10.27 (0.92) g/dl. Mean blood pressure, body weight, total blood volume and extracellular fluid compartment remained unchanged. Cardiac output as measured with a radionuclide method increased significantly from 4622 (1069) to 5393 (1285) units (p < 0.02) and peripheral resistance decreased from 22 (4) to 19 (3) units (p < 0.02). 6-keto-1-α-prostaglandin decreased from 96.9 (54.4) to 61.6 (18.0) pg/ml (p < 0.05) but plasma renin activity, noradrenalin and atrial natriuretic peptide remained unchanged comparing pre- and post-treatment levels. This observation suggests that an increase of red blood cell mass can improve heart function in patients undergoing regular dialysis treatment.