par Kumps, Alain 
Référence Therapeutic drug monitoring, 3, 3, page (271-274)
Publication Publié, 1981
Référence Therapeutic drug monitoring, 3, 3, page (271-274)
Publication Publié, 1981
Article révisé par les pairs
| Résumé : | Carbamazepine serum levels have been determined by gas-liquid chromatography in 24 children and 26 adults with epilepsy on chronic carbamazepine treatment. A significant correlation has been found between carbamazepine steady-state levels and doses per kilogram body weight in both children (p <0.01) and adults (p <0.05). This relationship is characterized by a significant decline in the level/dose ratio with the doses for adults (p <0.001) and, to a lesser extent, for children (p <0.05). These results are consistent with a dose-dependent bioavailability. |
