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Effects of fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia

par Malmendier, Claude ;Delcroix, Claude
Référence Atherosclerosis, 55, 2, page (161-169)
Publication Publié, 1985

Article révisé par les pairs

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Résumé :

This study investigates the influence of pharmacological doses of fenofibrate on HDL and LDL metabolism in 5 familial hypercholesterolemia heterozygotes. Fenofibrate lowered plasma low density lipoprotein cholesterol (20%, P < 0.025), triglycerides (37%: P < 0.005) and apolipoprotein B (14%: P < 0.05) but increased apo A-I (20%; P = 0.01). Kinetic studies showed that the drug markedly increased the fractional catabolic rate of LDL-apo B by 59% and its synthetic rate by 36%. Fractional catabolic rate of apo A-I was also increased by 26% but accompanied by a much greater increase of its synthetic rate (49%). Thus the change in balance between catabolism and synthesis of both apoproteins affected by fenofibrate accounts for the observed plasma concentration changes, which may be considered as favourable with regard to the management of atherosclerosis.