par Malmendier, Claude 
;Ameryckx, Jean Pierre
Référence Clinica chimica acta, 111, 2-3, page (267-270)
Publication Publié, 1981
;Ameryckx, Jean Pierre Référence Clinica chimica acta, 111, 2-3, page (267-270)
Publication Publié, 1981
Article révisé par les pairs
| Résumé : | The experimental subject received 125 g of glucose per day as the sole energy source for 6 days. At the end of this period the HDL apoprotein composition was modified, and the new peptides for 2 to 3% of total HDL proteins. In the previously described patients as much as 25% of the HDL proteins were abnormal. Almost all these patients had serious neurological problems, were unconscious, confined to bed and received, in addition to glucose perfusions, either discontinuous 40% mannitol infusions, antibiotics and/or dexamethasone. Most of them were slightly anemic or had a reduction in hematocrit value resulting from the perfusions. Although many factors may possibly aggravate the alteration in apoprotein composition, the single use of parenteral glucose alone is able to increase the amount of new apoproteins in HDL. As these new polypeptides were found in the plasma in relation to the carbohydrate feeding, they were designated S (sugar-induced), of which the 'new' apoproteins already mentioned are polymorphic forms. The new polypeptides differ from any known apolipoprotein or fragments of apoprotein. A survey of the literature on protein sequences shows an identity of the first 36 N-terminal amino acids in one of our new polypeptides with the serum amyloid A protein (SAA). |
