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PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic bata-cell apoptosis via regulation of the BH3-only protein Bim.

par Santin Gomez, Izortze ;Moore, Fabrice ;Colli, Maikel Luis ;Gurzov, Esteban Nicolas ;Marselli, Lorella;Marchetti, Piero;Eizirik, Decio L.
Référence Diabetes (New York, N.Y.), 60, 12, page (3279-3288)
Publication Publié, 2011

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Titre:	PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic bata-cell apoptosis via regulation of the BH3-only protein Bim.
Auteur:	Santin Gomez, Izortze; Moore, Fabrice; Colli, Maikel Luis; Gurzov, Esteban Nicolas; Marselli, Lorella; Marchetti, Piero; Eizirik, Decio L.
Informations sur la publication:	Diabetes (New York, N.Y.), 60, 12, page (3279-3288)
Statut de publication:	Publié, 2011
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Aged
	Animals
	Apoptosis -- drug effects -- genetics
	Apoptosis Regulatory Proteins -- genetics -- metabolism
	Blotting, Western
	Cell Survival -- drug effects -- genetics
	Cells, Cultured
	Diabetes Mellitus, Type 1 -- genetics -- metabolism
	Fluorescent Antibody Technique
	Humans
	Insulin-Secreting Cells -- cytology -- metabolism
	Interferon-alpha -- pharmacology
	Interferon-beta -- pharmacology
	Membrane Proteins -- genetics -- metabolism
	Protein Tyrosine Phosphatase, Non-Receptor Type 2 -- genetics -- metabolism
	Proto-Oncogene Proteins -- genetics -- metabolism
	RNA Interference
	Rats
	STAT1 Transcription Factor -- genetics -- metabolism
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0012-1797
	info:doi/10.2337/db11-0758
	info:pii/db11-0758
	info:scp/82255185820
	info:pmid/21984578
	PMC3219938