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Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

par Florence, Xavier ;Desvaux, Vincent;Goffin, Eric;de Tullio, Pascal;Pirotte, Bernard;Lebrun, Philippe
Référence European journal of medicinal chemistry, 80C, page (36-46)
Publication Publié, 2014-04

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Titre:	Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?
Auteur:	Florence, Xavier; Desvaux, Vincent; Goffin, Eric; de Tullio, Pascal; Pirotte, Bernard; Lebrun, Philippe
Informations sur la publication:	European journal of medicinal chemistry, 80C, page (36-46)
Statut de publication:	Publié, 2014-04
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Aorta -- cytology -- drug effects -- physiology
	Biological Transport -- drug effects
	Calcium -- metabolism
	Chromans -- chemistry
	Cromakalim -- chemistry -- pharmacology
	Dose-Response Relationship, Drug
	Insulin -- secretion
	Insulin-Secreting Cells -- drug effects -- secretion
	Ion Channel Gating -- drug effects
	Muscle Contraction -- drug effects
	Potassium Channels -- metabolism
	Potassium Chloride -- pharmacology
	Rats
	Stereoisomerism
	Structure-Activity Relationship
	Sulfur Compounds -- chemistry
Note générale:	JOURNAL ARTICLE
	SCOPUS: ar.j
Langue:	Autre
Identificateurs:	urn:issn:0223-5234
	info:doi/10.1016/j.ejmech.2014.04.024
	info:pii/S0223-5234(14)00343-2
	info:scp/84899090987
	info:pmid/24763361