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High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.

par Stijlemans, Benoît;Caljon, Guy;Natesan, Senthil Kumar A;Saerens, Dirk;Conrath, Katja;Perez-Morga, David ;Skepper, Jeremy N;Nikolaou, Alexandros;Brys, Lea;Pays, Etienne ;Magez, Stefan;Field, Mark C;De Baetselier, Patrick;Muyldermans, Serge
Référence P L o S Pathogens, 7, 6, page (e1002072)
Publication Publié, 2011-06

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Titre:	High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.
Auteur:	Stijlemans, Benoît; Caljon, Guy; Natesan, Senthil Kumar A; Saerens, Dirk; Conrath, Katja; Perez-Morga, David; Skepper, Jeremy N; Nikolaou, Alexandros; Brys, Lea; Pays, Etienne; Magez, Stefan; Field, Mark C; De Baetselier, Patrick; Muyldermans, Serge
Informations sur la publication:	P L o S Pathogens, 7, 6, page (e1002072)
Statut de publication:	Publié, 2011-06
Sujet CREF:	Sciences exactes et naturelles
	Sciences bio-médicales et agricoles
MeSH keywords:	Amino Acid Sequence
	Animals
	Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use
	Antibody Affinity
	Cells, Cultured
	Down-Regulation -- drug effects
	Endocytosis -- drug effects
	Humans
	Mice
	Mice, Inbred C57BL
	Models, Biological
	Models, Molecular
	Molecular Sequence Data
	Nanoparticles
	Trypanocidal Agents -- pharmacology -- therapeutic use
	Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure
	Trypanosomiasis, African -- immunology -- metabolism -- therapy
	Variant Surface Glycoproteins, Trypanosoma -- immunology
Note générale:	Evaluation Studies
	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:1553-7366
	info:doi/10.1371/journal.ppat.1002072
	info:pii/10-PLPA-RA-4101
	info:scp/79959851947
	info:pmid/21698216
	PMC3116811