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Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: Systematic review and meta-analysis of randomized trials.

par Del Mastro, Lucia;Ceppi, Marcello;Poggio, Francesca;Bighin, Claudia;Peccatori, Fedro Alessandro;Demeestere, Isabelle ;Levaggi, Alessia;Giraudi, Sara;Lambertini, Matteo ;D'Alonzo, Alessia;Canavese, Giuseppe;Pronzato, Paolo;Bruzzi, Paolo
Référence Cancer treatment reviews, 40, 5, page (675-83)
Publication Publié, 2014-06

Article révisé par les pairs

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Résumé :

The role of temporary ovarian suppression with gonadotropin-releasing hormone analogues (GnRHa) in the prevention of chemotherapy-induced premature ovarian failure (POF) is still controversial. We conducted a systematic review and meta-analysis of randomized trials evaluating the efficacy of GnRHa, given before and during chemotherapy, in the prevention of POF in premenopausal cancer patients.