A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.

Serretti, Alessandro; Chiesa, Alberto; Calati, Raffaella; Massat, Isabelle; Linotte, Sylvie; Kasper, Siegfried; Lecrubier, Yves; Antonijevic, Irina; Forray, Carlos; Snyder, Lenore; Bollen, Joseph; Zohar, Joseph; De Ronchi, Diana; Souery, Daniel; Mendlewicz, Julien

doi:doi/10.1016/j.jad.2010.06.025

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A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.

par Serretti, Alessandro ;Chiesa, Alberto ;Calati, Raffaella ;Massat, Isabelle

;Linotte, Sylvie

;Kasper, Siegfried ;Lecrubier, Yves ;Antonijevic, Irina ;Forray, Carlos ;Snyder, Lenore ;Bollen, Joseph ;Zohar, Joseph ;De Ronchi, Diana ;Souery, Daniel

;Mendlewicz, Julien

Référence Journal of affective disorders, 128, 1-2, page (56-63)
Publication Publié, 2011-01

Article révisé par les pairs

Résumé :

The transcription factor Cyclic adenosine monophosphate Response Element Binding (CREB) protein has been repeatedly involved in the aetiology and pharmacotherapy of major depression (MD). The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants.

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