par Massat, Isabelle 
;Aygun Kocabas, Neslihan ;Crisafulli, Concetta;Chiesa, Alberto;Calati, Raffaella;Linotte, Sylvie ;Kasper, Siegfried;Fink, Martin;Antonijevic, Irina;Forray, Carlos;Snyder, Lenore;Bollen, Joseph;Zohar, Joseph;De Ronchi, Diana;Souery, Daniel ;Serretti, Alessandro;Mendlewicz, Julien
Référence Neuroscience letters, 498, 3, page (218-221)
Publication Publié, 2011-07
;Aygun Kocabas, Neslihan ;Crisafulli, Concetta;Chiesa, Alberto;Calati, Raffaella;Linotte, Sylvie ;Kasper, Siegfried;Fink, Martin;Antonijevic, Irina;Forray, Carlos;Snyder, Lenore;Bollen, Joseph;Zohar, Joseph;De Ronchi, Diana;Souery, Daniel ;Serretti, Alessandro;Mendlewicz, Julien Référence Neuroscience letters, 498, 3, page (218-221)
Publication Publié, 2011-07
Article révisé par les pairs
| Résumé : | Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG+AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p=0.04). Rs4680 genotype was associated with early onset BD as well (p=0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes. |
