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Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.

par Lysandropoulos, Andreas ;Jaquiéry, Emilie;Jilek, Samantha;Pantaleo, Giuseppe;Schluep, Myriam;Du Pasquier, Renaud A
Référence Journal of neuroimmunology, 233, 1-2, page (240-244)
Publication Publié, 2011-04

Article révisé par les pairs

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Résumé :

Little is known on a putative effect of vitamin D on CD8+ T cells. Yet, these cells are involved in the immmunopathogenesis of MS. We assessed the cytokine profile of EBV-specific CD8+ T cells of 10 early MS patients and 10 healthy control subjects with or without 1,25(OH)(2)D(3) and found that, with 1,25(OH)(2)D(3), these cells secreted less IFN-γ and TNF-α and more IL-5 and TGF-β. CD4+ T cell depletion or even culture with CD8+ T cells only did not abolish the immunomodulatory effect of 1,25(OH)(2)D(3) on CD8+ T cells, suggesting that 1,25(OH)(2)D(3) can act directly on CD8+ T cells.