par Hermans, Michel P;Pepersack, Thierry 
;Godeaux, Lionel H;Beyer, Ingo ;Turc, André P
Référence The journals of gerontology. Series A, Biological sciences and medical sciences, 60, 2, page (241-247)
Publication Publié, 2005-02
;Godeaux, Lionel H;Beyer, Ingo ;Turc, André PRéférence The journals of gerontology. Series A, Biological sciences and medical sciences, 60, 2, page (241-247)
Publication Publié, 2005-02
Article révisé par les pairs
| Résumé : | Although diabetes in elderly persons is generally type 2, the metabolic abnormalities associated with aging suggest that elderly persons may differ from younger persons with type 2 diabetes. In addition, nonobese elderly persons with type 2 diabetes show a marked impairment in insulin release accompanied by mild insulin resistance, whereas obese elderly persons have marked insulin resistance in the presence of "adequate" levels of insulin. Other factors that could adversely affect glucose tolerance in aging include drug use, associated disease, and other stressful conditions commonly encountered in geriatric inpatients units. The authors' objectives in this study were 1) to prospectively assess the prevalence of glucose homeostasis abnormalities among elderly hospitalized patients and the degree to which it reflects abnormalities in insulin secretion or insulin sensitivity using homeostasis model assessment of fasting glucose, insulin, and C-peptide; and 2) to define the social, functional, pathologic, and nutritional characteristics of persons with impaired glucose tolerance or diabetes. |
