Article révisé par les pairs
Titre:
  • Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
Auteur:Takiishi, Tatiana; Korf, Hannelie; Van Belle, Tom L; Robert, Sofie; Grieco, Fabio Arturo; Caluwaerts, Silvia; Galleri, Letizia; Spagnuolo, Isabella; Steidler, Lothar; Van Huynegem, Karolien; Demetter, Pieter; Wasserfall, Clive; Atkinson, Mark; Dotta, Francesco; Rottiers, Pieter; Gysemans, Conny; Mathieu, Chantal
Informations sur la publication:The Journal of clinical investigation, 122, 5, page (1717-1725)
Statut de publication:Publié, 2012-05
Sujet CREF:Anatomopathologie
MeSH keywords:Animals
Antigens, CD3 -- immunology
Autoantigens -- biosynthesis -- genetics
Cell Count
Cell Proliferation
Combined Modality Therapy
Diabetes Mellitus, Type 1 -- immunology -- therapy
Humans
Hypoglycemic Agents -- therapeutic use
Immune Tolerance
Immunologic Factors -- therapeutic use
Immunosuppression
Insulin -- metabolism
Insulin-Secreting Cells -- metabolism -- pathology
Interleukin-10 -- biosynthesis -- genetics -- secretion
Intestinal Mucosa
Lactococcus lactis -- genetics -- metabolism
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Proinsulin -- biosynthesis -- genetics -- secretion
T-Lymphocytes, Regulatory -- metabolism -- physiology
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: no.j
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0021-9738
info:doi/10.1172/JCI60530
info:pii/60530
info:scp/84896830542
info:pmid/22484814
PMC3336982

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