par Le Moine, Alain ;Benghaiat, F S;De Wilde, Virginie ;Vokaer, Benoît ;Charbonnier, Louis-Marie ;Goldman, Michel
Référence Bulletin et mémoires de l'Académie royale de médecine de Belgique, 164, 5-6, page (230-239)
Publication Publié, 2009
Article révisé par les pairs
Résumé : Naturally occurring regulatory T-cells (Tregs) play a critical role in the homeostasis of healthy immune system. A Treg deficiency is responsible for immune system dysregulation, immune hyperreactivity and autoimmunity. Herein, we investigated the role of Tregs, either in the context of antibody-induced transplantation tolerance, mixed donor/recipient chimerism or in models of spontaneous graft acceptance without immunosuppression. We also investigated their capacities to control endotoxin-mediated immune response in the context of lymphopaenia-driven homeostatic T-cell proliferation. Finally, although Tregs adequately control Th1 and Th2 immunity, they are inefficient in regulating IL-17 producing T cells in vitro and in vivo and rather promote them.