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Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation.

par Treede, Hendrik;Glanville, Allan R.;Klepetko, Walter;Aboyoun, Christina;Vettorazzi, Eik;Lama, Raffael;Bravo, Carlos;Knoop, Christiane ;Aubert, John-David;Reichenspurner, Hermann;European and Australian Investigators in Lung Transplantation,
Référence The Journal of heart and lung transplantation, 31, 8, page (797-804)
Publication Publié, 2012-08

Article révisé par les pairs

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Résumé :

Chronic lung allograft dysfunction, which manifests as bronchiolitis obliterans syndrome (BOS), is recognized as the primary cause of morbidity and mortality after lung transplantation. In this study we assessed the efficacy and safety of two de novo immunosuppression protocols to prevent BOS.