par Donadello, Katia ;Cristallini, Stefano;Taccone, Fabio ;Lorent, Sophie ;Vincent, Jean Louis ;De Backer, Daniel ;Jacobs, Frédérique
Référence International journal of antimicrobial agents, 42, 6, page (580-583)
Publication Publié, 2013-12
Référence International journal of antimicrobial agents, 42, 6, page (580-583)
Publication Publié, 2013-12
Article révisé par les pairs
Résumé : | We report the case of an immunosuppressed patient with Strongyloides disseminated infection who was successfully treated with the veterinary parenteral form of ivermectin. A kidney transplant recipient developed disseminated infection with Strongyloides stercoralis. Because oral treatment with ivermectin was not possible, subcutaneous ivermectin (75 µg/kg/day, then 200 µg/kg/day) was given for 9 days, with clinical improvement and disappearance of all larvae. Serum ivermectin concentrations were between 15.6 ng/mL and 19.7 ng/mL during the 9 days of therapy; however, drug accumulation (plasma levels >40 ng/mL) 48 h after discontinuation of therapy was associated with the development with encephalopathy. We also review all cases of human disseminated Strongyloides infection treated with parenteral ivermectin. |