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Correction of all-trans retinoic acid deficiency in alcoholic cirrhosis lessens the excessive inflammatory monocyte response: a translational study.

par Ouziel, Romy ;Trepo, Eric ;Cremer, Anneline ;Moreno, Christophe ;Degré, Delphine ;Chaouni, Mustapha ;Vercruysse, Vincent ;Quertinmont, Eric ;Devière, Jacques ;Lemmers, Arnaud ;Gustot, Thierry
Référence Liver international
Publication Publié, 2013-06

Article révisé par les pairs

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Résumé :

Patients with alcoholic liver disease (ALD) have vitamin A (VA) deficiency and an enhanced immune response associated with disease severity. All-trans retinoic acid (ATRA), a VA-active metabolite, has anti-inflammatory effects and its deficiency could contribute to the exacerbated proinflammatory reaction. The aim of this study was to investigate the effects of ATRA/VA deficiency and supplementation on the monocyte response in ALD.