par Schepers, Kinda ;Hernandez, Antonio;Andrei, Graciela;Gillemot, Sarah;Fiten, Pierre;Opdenakker, Ghislain;Bier, Jean Christophe ;David, Philippe ;Delforge, Marie-Luce ;Jacobs, Frédérique ;Snoeck, Robert
Référence Journal of clinical virology, 59, 1, page (67-70)
Publication Publié, 2014-01
Référence Journal of clinical virology, 59, 1, page (67-70)
Publication Publié, 2014-01
Article révisé par les pairs
Résumé : | Herpes simplex virus is the most common cause of severe sporadic encephalitis. We report a case of herpes simplex type 1-encephalitis in a 50-year-old woman receiving anti-tumor necrosis factor-α monoclonal antibodies adalimumab. Although she was an acyclovir naïve patient, a mixed viral population (wild-type and acyclovir-resistant bearing a thymidine-kinase mutation) was identified in the cerebrospinal fluid. The virus in cerebrospinal fluid evolved and a second thymidine-kinase mutant virus emerged. Combined foscavir and acyclovir treatment resolved the herpes simplex encephalitis. To our knowledge, this is the first report of acyclovir-resistant herpes simplex encephalitis in a patient treated with adalimumab. |