Potent antiproliferative cembrenoids accumulate in tobacco upon infection with Rhodococcus fascians and trigger unusual microtubule dynamics in human glioblastoma cells.

Nacoulma, Aminata; Megalizzi, Véronique; Pottier, Laurent R; De Lorenzi, Manuela; Thoret, Sylviane; Dubois, Joëlle; Vandeputte, Olivier M.; Duez, Pierre; Vereecke, Danny; El Jaziri, Mondher

doi:doi/10.1371/journal.pone.0077529

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Potent antiproliferative cembrenoids accumulate in tobacco upon infection with Rhodococcus fascians and trigger unusual microtubule dynamics in human glioblastoma cells.

par Nacoulma, Aminata

;Megalizzi, Véronique

;Pottier, Laurent R ;De Lorenzi, Manuela

;Thoret, Sylviane ;Dubois, Joëlle ;Vandeputte, Olivier M.

;Duez, Pierre

;Vereecke, Danny ;El Jaziri, Mondher

Référence PloS one, 8, 10, page (e77529)
Publication Publié, 2013

Article révisé par les pairs

Résumé :

Though plant metabolic changes are known to occur during interactions with bacteria, these were rarely challenged for pharmacologically active compounds suitable for further drug development. Here, the occurrence of specific chemicals with antiproliferative activity against human cancer cell lines was evidenced in hyperplasia (leafy galls) induced when plants interact with particular phytopathogens, such as the Actinomycete Rhodococcus fascians.

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