par Corbiere, Véronique 
;Nicolay, H;Russo, V.;Stroobant, V;Brichard, Vincent ;Boon, Thierry;van der Bruggen, P
Référence Tissue antigens, 63, 5, page (453-457)
Publication Publié, 2004-05
;Nicolay, H;Russo, V.;Stroobant, V;Brichard, Vincent ;Boon, Thierry;van der Bruggen, PRéférence Tissue antigens, 63, 5, page (453-457)
Publication Publié, 2004-05
Article révisé par les pairs
| Résumé : | "Cancer germline" genes such as those of the MAGE family are expressed in many tumors and in male germline cells but are silent in normal tissues. They encode shared tumor-specific antigens that have been used in therapeutic vaccination trials of cancer patients. We report the identification of a new MAGE-1-encoded peptide that is recognized by a cytolytic T-lymphocyte (CTL) clone on human leukocyte antigen (HLA)-B*5701. The sequence of the peptide, corresponding to position 102-112 of the MAGE-1 protein sequence, is ITKKVADLVGF. When tumor cells expressing MAGE-1 were transfected with HLA-B*5701, they were lyzed by the CTL clone, indicating that the peptide is processed in tumor cells and can, therefore, be used as a target for anti-tumoral vaccination. |
