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Histology as a potential clinical predictor of outcome in advanced non-small-cell lung cancer treated with vinorelbine and mitomycin combination chemotherapy.

par Wibmer, Thomas;Berghmans, Thierry ;Kropf-Sanchen, Cornelia;Lafitte, Jean-Jacques;Rüdiger, Stefan;Paesmans, Marianne ;Blanta, I;Scherpereel, Arnaud;Stoiber, Kathrin M;Rottbauer, Wolfgang;Sculier, Jean-Paul ;Schumann, Christian
Référence Lung, 191, 3, page (271-280)
Publication Publié, 2013-06

Article révisé par les pairs

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Résumé :

The importance of clinical predictors in the treatment of non-small-cell lung cancer (NSCLC) has increased during the last decade. This retrospective study analyzed the combined patient-level data from two phase II trials that investigated the efficacy and safety of combination chemotherapy with vinorelbine and mitomycin in patients with locally advanced or metastatic NSCLC. The aim of this analysis was to determine if patients' baseline and disease characteristics, including histology, gender, smoking history, and expression of TTF-1, might be potential predictors of outcome.